PRINCIPAIS PUBLICAÇÕES (sublinhado alunos e em negrito docentes do laboratório)

2015.

i) Casa, Diani Meza; Moraes Carraro, Talita Cristina Moreira; De Camargo, Luciana Erzinger Alves ; Dalmolin, Luciana Facco; Khalil, Najeh Maissar ; Mainardes, Rubiana Mara . Poly(L-lactide) Nanoparticles Reduce Amphotericin B Cytotoxicity and Maintain Its In Vitro Antifungal Activity. Journal of Nanoscience and Nanotechnology (Print), v. 15, p. 848-854, 2015.

 

ii) OLIVEIRA, Olga Maria Mascarenhas de Faria ; BRUNETTI, IGUATEMY L ; KHALIL, Najeh Maissar . Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system. Anais da Academia Brasileira de Ciências (Impresso), v. 87, p. 183-192, 2015.

 

iii) LINDNER, G. R. ; Santos, D. B. ; Colle, D. ; MOREIRA, E. L. G. ; Prediger, R. D. ; Farina, M. ; KHALIL, Najeh Maissar ; MAINARDES, Rubiana Mara . Improved neuroprotective effects of resveratrol loaded polysorbate 80 coated PLA nanoparticles in MPTP-induced parkinsonism. Nanomedicine, 2015.

 

iv) ANTONIO, E. ; KHALIL, Najeh Maissar ; MAINARDES, Rubiana Mara. Bovine Serum Albumin Nanoparticles Containing Quercetin: Characterization And Antioxidant Activity. Journal of Nanoscience and Nanotechnology (Print), 2015.

 

v) LINDNER, G. R. ; DALMOLIN, L. F. ; KHALIL, Najeh Maissar ; MAINARDES, Rubiana Mara. Influence of the formulation parameters on the particle size and encapsulation efficiency of resveratrol in PLA and PLA-PEG blend nanoparticles: a factorial design. Journal of Nanoscience and Nanotechnology (Print), 2015.

 

vi) CASA, D. M. ; KARAM, T. K. ; ALVES, A. C. S. ; ZGODA, A. A. ; KHALIL, Najeh Maissar ; MAINARDES, Rubiana Mara. Bovine Serum Albumin Nanoparticles Containing Amphotericin B: Characterization, Cytotoxicity And In Vitro Antifungal Evaluation. Journal of Nanoscience and Nanotechnology (Print), 2015.

 

vii) CARRARO, T. C. M. M. ; KHALIL, Najeh Maissar ; MAINARDES, Rubiana Mara. Amphotericin B-loaded polymeric nanoparticles: formulation optimization by factorial design. Pharmaceutical Development and Technology, v. x, p. 1-7, 2015.

 

2014.

i) CASA, D. M. ; CARRARO, T. C. M. M. ; CAMARGO, L. E. A. ; DALMOLIN, L. F. ; KHALIL, Najeh Maissar ; MAINARDES, Rubiana Mara. Poly(L-lactide) nanoparticles reduce amphotericin B cytotoxicity and maintain its in vitro antifungal activity. Journal of Nanoscience and Nanotechnology (Print), v. xxx, p. xxx, 2014.

 
ii) RODRIGUES, C. D. ; KHALIL, Najeh Maissar ; MAINARDES, Rubiana Mara . Determination of Amphotericin B in PLA-PEG blend nanoparticles by an HPLC-PDA method. Brazilian Journal of Pharmaceutical Sciences (Impresso), v. xxx, p. xxx, 2014.

 

iii) Cótica, L.F. ; Freitas, V.F. ; SILVA, D. M. ; HONJOYA, K. ; Santos, I.A. ; FONTANIVE, V. C. P. ; KHALIL, NAJEH MAISSAR ; MAINARDES, Rubiana Mara ; KIOSHIMA, E. S. ; GUO, R. ; BHALLA, A. S. . Thermal decomposition synthesis and assessment of effects on blood cells and in vivo damages of cobalt ferrite nanoparticles. Journal of Nano Research (Online), v. xxx, p. xxx, 2014.

 

iv) FONTANIVE, V. C. P. ; KHALIL, Najeh Maissar ; Cótica, L.F. ; MAINARDES, Rubiana Mara . Aspectos físicos e biológicos de nanopartículas de ferritas magnéticas. Revista de Ciências Farmacêuticas Básica e Aplicada,  2014.

 

2013.

i) KHALIL, NAJEH MAISSAR ; NASCIMENTO, T.C.F. ; DALMOLIN, L. F. ; CASA, D. M. ; HOSS, I. ; ROMANO, M. A. ; MAINARDES, RUBIANA MARA. Pharmacokinetics of curcumin-loaded plga and PLGA-PEG blend nanoparticles after oral administration in rats. Colloids and Surfaces. B, Biointerfaces (Print), v. 101, p. 353-360, 2013.

ii) MATTOS, A. C. ; KHALIL, NAJEH MAISSAR ; MAINARDES, RUBIANA MARA . Development and validation of an HPLC method for the determination of fluorouracil in polymeric nanoparticles. Brazilian Journal of Pharmaceutical Sciences (Impresso), v. 49, p. 117-126, 2013.

iii) KHALIL, NAJEH MAISSAR ; MATTOS, A. C. ; CARRARO, T. C. M. M. ; LUDWIG, D. B. ; MAINARDES, RUBIANA MARA. Nanotechnological strategies for the treatment of neglected diseases. Current Pharmaceutical Design (Print),  2013.

iv) PEDROSO, L. S. ; FAVERO, G. M. ; CAMARGO, L. E. A. ; MAINARDES, RUBIANA MARA ; KHALIL, NAJEH MAISSAR. Effect of the o-methyl catechols apocynin, curcumin and vanillin on the cytotoxicity activity of tamoxifen. Journal of Enzyme Inhibition and Medicinal Chemistry (Print), v. 28(4), p.734-40, 2013.

v) RODRIGUES, C. D. ; CASA, D. M. ; DALMOLIN, L. F. ; CAMARGO, L. E. A. ; KHALIL, NAJEH MAISSAR ; MAINARDES, RUBIANA MARA . AMPHOTERICIN B-LOADED POLY(LACTIDE)-POLY(ETHYLENE GLYCOL)-BLEND NANOPARTICLES: CHARACTERIZATION AND IN VITRO EFFICACY AND TOXICITY. Current Nanoscience, v. 9, p. 594-598, 2013.

vi) QUADROS, A. U. ; KHALIL, NAJEH MAISSAR ; DALPOSSO, L.M. ; KARAM, T. K. ; MAINARDES, RUBIANA MARA . Efeito da nicotina sobre fagócitos ativados. Acta Scientiarum. Health Sciences (Impresso), v. 35, p. 105-109, 2013.

vii) HAKIME, Ricardo ; VELLOSA, José Carlos ; KHALIL, NAJEH MAISSAR ; KHALIL, O. A. K. ; BRUNETTI, Iguatemy Lourenço ; OLIVEIRA, Olga Maria Mascarenhas de Faria . Chemical, enzymatic, and cellular antioxidant activity studies for Agaricus blazei Murrill. Anais da Academia Brasileira de Ciências (Impresso), v. 85, p.1073-81, 2013.

viii) LINDNER, G. ; KHALIL, Najeh Maissar ; MAINARDES, Rubiana Mara . Resveratrol-Loaded Polymeric Nanoparticles: Validation of an HPLC-PDA Method to Determine the Drug Entrapment and Evaluation of Its Antioxidant Activity. The Scientific World Journal, v. 2013, p. 1-9, 2013.

2012.

i) BELTRAME, F.L. ; MAINARDES, RUBIANA MARA ; KHALIL, NAJEH MAISSAR ; PRESTES, R.A. ; NOGUEIRA, A. ; CASS, Q. B. A quantitative validated method using liquid chromatography and chemometric analysis for evaluation of raw material of Maytenus ilicifolia (Schrad.) Planch., Celastraceae.. Química Nova (Impresso), v. 35, p. 327-331, 2012.

ii) VENDRAME, S.C. ; CÓTICA, L.F. ; FREITAS, V.F. ; DIAS, G. S. ; SANTOS, I.A. ; KHALIL, NAJEH MAISSAR ; MAINARDES, RUBIANA MARA ; STARUCH, M. ; JAIN, M.  Simple and facile approach to synthesize magnetite nanoparticles and assessment of their effects on blood cells. Journal of Magnetism and Magnetic Materials, v. 324, p. 559-563, 2012.

iii) KHALIL, O. A. K. ; OLIVEIRA, OLGA MARIA MASCARENHAS DE FARIA ; VELLOSA, JOSÉ CARLOS ; QUADROS, A. U. ; DALPOSSO, L.M. ; KARAM, T. K. ; MAINARDES, RUBIANA MARA ; KHALIL, NAJEH MAISSAR. Curcumin antifungal and antioxidant activities are increased in the presence of ascorbic acid. Food Chemistry, v. 133, p. 1001-1005, 2012.

iv) NASCIMETO, T.C.F. ; CASA, D. M. ; DALMOLIN, L. F. ; MATTOS, A. C. ; KHALIL, NAJEH MAISSAR ; MAINARDES, RUBIANA MARA. Development and validation of an HPLC method using fluorescence detection for the quantitative determination of curcumin from PLGA and PLGA-PEG nanoparticles. Current Pharmaceutical Analysis, v. 8, p. 324-333, 2012.

v) MENDES, J.B.E. ; RIEKES, M.K. ; OLIVEIRA, V.M. ; MICHEL, M.D. ; KHALIL, NAJEH MAISSAR ; ZAWADZI, S.F. ; MAINARDES, RUBIANA MARA ; FARAGO, P. V. PHBV/PCL Microparticles for Controlled Release of Resveratrol: Physicochemical Characterization, Antioxidant Potential and Effect on Hemolysis of Human Erythrocytes. The Scientific World Journal, p. 542937, 2012.

vi) MAINARDES, RUBIANA MARA; GREMIÃO, M. P. D. Nanoencapsulation and Characterization of Zidovudine on Poly(L-lactide) and Poly(L-lactide) Poly(ethylene glycol)-Blend Nanoparticles. Journal of Nanoscience and Nanotechnology (Print), v. 12, p. 8513-8521, 2012.

2011.

i) KHALIL, NAJEH MAISSAR ; CARRRO, E ; CÓTICA, L.F. ; MAINARDES, RUBIANA MARA. Potential of polymeric nanoparticles in AIDS treatment and prevention. Expert Opinion on Drug Delivery (Print), v. 08, p. 95-112, 2011.

2010.

i) PETACCI, FERNANDO ; FREITAS, SILVIA S ; BRUNETTI, IGUATEMY L ; KHALIL, NAJEH MAISSAR. Inhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae). Biological Research (Print), v. 43, p. 63-74, 2010.

ii) MAINARDES, RUBIANA MARA ; KHALIL, NAJEH MAISSAR ; GREMIÃO, MARIA PALMIRA DAFLON. Intranasal delivery of zidovudine by PLA and PLA-PEG blend nanoparticles. International Journal of Pharmaceutics (Print), v. 365, p. 266-271, 2010.

iii) DALLA SANTA H. S. ; RUBEL, R. ; FERNANDES, L. C. ; BONATTO, S. J. R. ; BELLO, S. R. ; MONTEIRO, M. C. ; KHALIL, NAJEH MAISSAR ; SANTA, O. R. D. ; GERN, J. C. ; SOCCOL, C. R. . Agaricus brasiliensis-enriched functional product promotes in mice increase in HDL levels and immunomodulate to Th1 CD4+T subsets. A. brasiliensis functional product and biological benefits. Current Trends in Biotechnology and Pharmacy, v. 4, p. 957-970, 2010.

2009.

i) ASSIS, SANDRA APARECIDA DE ; VELLOSA, JOSÉ CARLOS ; KHALIL, NAJEH MAISSAR ; BRUNETTI, IGUATEMY LOURENÇO ; LEITE, KATIA MARIA DA SILVA CERQUIRA ; MARTINS, A. B. G. ; OLIVEIRA, OLGA MARIA MASCARENHAS DE FARIA. Antioxidant activity, ascorbic acid and total phenol of exotic fruits ocuring in Brazil. International Journal of Food Sciences and Nutrition, v. 60, p. 439-448, 2009.

ii)  MAINARDES, RUBIANA MARA ; GREMIÃO, MARIA PALMIRA DAFLON ; FONSECA, LUIZ MARCOS DA ; BRUNETTI, IGUATEMY LOURENÇO ; KHALIL, NAJEH MAISSAR. Zidovudine-Loaded PLA and PLA-PEG blend nanoparticles: influence of polymeric Composition on Phagocytic Uptake by Polymorphonuclear cells. Journal of Pharmaceutical Sciences, v. 98, p. 257-267, 2009.

iii)  VELLOSA, JOSÉ CARLOS ; KHALIL, NAJEH MAISSAR ; GUTIERRES, V. O. ; SANTOS, V. A. F. F. M. ; FURLAN, MAYSA ; BRUNETTI, IGUATEMY LOURENÇO ; OLIVEIRA, OLGA MARIA MASCARENHAS DE FARIA. Salacia campestris Root Bark Extract: Peroxidase Inhibition, Antioxidant and Antiradical Profile. Revista Brasileira de Ciências Farmacêuticas (Cessou em 2008. Cont. ISSN 1984-8250 Brazilian Journal of Pharmaceutical Sciences), v. 45, p. 99-107, 2009.

iv) KHALIL, NAJEH MAISSAR ; MAINARDES, RUBIANA Mara. Colloidal polymeric nanoparticles and brain drug delivery. Current Drug Delivery, v. 6, p. 261-273, 2009.

v) URBAN, MARIA CRISTINA COCENZA ; MAINARDES, RUBIANA MARA ; GREMIÃO, MARIA PALMIRA DAFLON. Development and validation of HPLC method for analysis of dexamethasone acetate in microemulsions. Brazilian Journal of Pharmaceutical Sciences (Impresso), v. 45, p. 87-92, 2009.

vi) MAINARDES, RUBIANA MARA; GREMIÃO, M. P. D.  Reversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administration. Biological Research (Print), v. 42, p. 357-364, 2009.

2008.

i) REGASINI, L. O. ; VELLOSA, José Carlos ; SILVA, D. H. S. ; FURLAN, M ; OLIVEIRA, Olga Maria Mascarenhas de Faria ; KHALIL, NAJEH MAISSAR ; BRUNETTI, Iguatemy Lourenço ; YOUNG, M. C. M. ; BARREIRO, E. J. ; BOLZANI, V. S. . Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors. Phytochemistry, v. 69, p. 1739-1744, 2008.

ii) GONCALVES, D. ; KHALIL, NAJEH MAISSAR ; OLIVEIRA, OLGA MARIA MASCARENHAS DE FARIA ; ORRICO, S. R. P. Effect of Non-surgical periodontal therapy on peroxidase activity in diabetic patients. Journal of Clinical Periodontology, v. 35, p. 799-806, 2008.

iii) PEPATO, M. P. ; KHALIL, NAJEH MAISSAR ; GIOCONDO, M. P. ; BRUNETTI, IGUATEMY LOURENÇO . Vanadium and its complexes: the renewed interest in its biochemistry. Acta Farmaceutica Bonaerense, v. 27, p. 468-476, 2008.

iv) KITAGAWA, RODRIGO REZENDE ; FONSECA, LUIZ MARCOS DA ; XIMENES, VALDECIR FARIA ; KHALIL, NAJEH MAISSAR ; VILEGAS, WAGNER ; RADDI, MARIA STELLA GONÇALVES . Ascorbic acid potentiates the cytotoxicity of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin. Phytochemistry, v. 69, p. 2205-2208, 2008.

v) VELLOSA, JOSÉ CARLOS ; KHALIL, O. A. K. ; KHALIL, NAJEH MAISSAR ; FORMENTON, V. A. F. ; FURLAN, M ; BRUNETTI, IGUATEMY LOURENÇO ; OLIVEIRA, OLGA MARIA MASCARENHAS DE FARIA ; HAKIME, RICARDO. Maytenus ilicifolia as antioxidants and anti-radicals source and its action over neutrophil peroxidase (myeloperoxidase). African Journal of Biochemistry Research, v. 2, p. 232-239, 2008.

vi) KHALIL, NAJEH MAISSAR; PEPATO, MARIA T ; BRUNETTI, IGUATEMY L. Free Radical Scavenging Profile and Myeloperoxidase Inhibition of Extracts from Antidiabetic Plants: Bauhinia forficata and Cissus sicyoides. Biological Research, v. 41, p. 165-171, 2008.

2006.

i) MARA MAINARDES, RUBIANA ; OLIVEIRA CINTO, PRISCILA ; CESAR EVANGELISTA, RAUL ; PALMIRA DAFLON GREMIAO, MARIA ; MAINARDES, R. M. Liposomes and Micro/Nanoparticles as Colloidal Carriers for Nasal Drug Delivery. Current Drug Delivery, v. 3, n.3, p. 275-285, 2006.

ii) MARA MAINARDES, RUBIANA; GREMIÃO, MARIA PALMIRA DAFLON ; EVANGELISTA, RAUL CESAR. Development of Praziquantel-Loaded PLGA Nanoparticles and Evaluation of Intestinal Permeation by the Everted Gut Sac Model. Journal of Nanoscience and Nanotechnology, v. 6, p. 3057-3061, 2006.

iii) MARA MAINARDES, RUBIANA; CINTO, P. O. ; GREMIÃO, M. P. D. High-performance liquid chromatography determination of praziquantel in tablets and raw materials. Acta Farmaceutica Bonaerense, v. 25, p. 567-570, 2006.

iv) MAINARDES, RUBIANA MARA ; GREMIÃO, MARIA PALMIRA DAFLON ; EVANGELISTA, RAUL CESAR. Thermoanalytical study of praziquantel-loaded PLGA nanoparticles. RBCF. Revista Brasileira de Ciências Farmacêuticas, v. 42, p. 523-530, 2006.

2005.

i) MAINARDES, RUBIANA MARA ; URBAN, MARIA CRISTINA COCENZA ; CHAUD, MARCO VINICIUS ; KHALIL, NAJEH MAISSAR ; CINTO, PRISCILA OLIVEIRA ; EVANGELISTA, RAUL CESAR ; GREMIÃO, MARIA PALMIRA DAFLON. Colloidal carriers for ophthalmic drug delivery. Current Drug Targets, v. 6, n.3, p. 363-371, 2005.

ii) MARA MAINARDES, RUBIANA; EVANGELISTA, R. C. Praziquantel-loaded PLGA nanoparticles: preparation and characterization. Journal of Microencapsulation, London, v. 22, n.1, p. 13-24, 2005.

iii)  MARA MAINARDES, RUBIANA;  EVANGELISTA, R. C. PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution. International Journal of Pharmaceutics, Amsterdam, v. 290, n.1-2, p. 137-144, 2005.

2004.

i) MARA MAINARDES, RUBIANA; SILVA, LUCIANO P. Drug Delivery Systems: Past, Present, and Future. Current Drug Targets, Hilversum, v. 5, n.5, p. 449-455, 2004.